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KMID : 0367419700130010002
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Journal of Korean Pediatric Society
1970 Volume.13 No. 1 p.2 ~ p.22
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Experimental Studies on the Influences of the Injection of Chlorpromazine in the Central Nervous System upon Body Temperature
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Abstract
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Chlorpromazine exerts important effect on the central nervous system. The actions c.f the chlorpromazine on the central nervous system are still not well understood although Cris hove been studied extensively. The exact site of hypothermic action of chlorpromazine has- not keen determined
The present study was undertaken -to determine central sites of= body temperature re?Marion produced by injection of chlorpromazine into brain directly with X30 gauze needle in rabbi´s fixed in s erotaxic apparatus. Male rabbit of 1. bkg.. weight were used.
Rectal temperature were measured usinga thermometer: The rabbit were not starved before us food and t;cater \vere withheld during experiments.
The results were as- follows;
1 When p. 1mg of chlorpromazine was administered to the rabbit tramuscularly or intravenou 1 there was not any hypothermic action.
2. Same amounts of chlorpromazine didn´t show any significant hypothermic action when chlorpromazine was administered to the cerebral cortex; cerebellum, putamen and I ippocampus.
3. Injection of same amount of chlorpromazine into the caudate nucleus, midbrain, acnygdala, and posterior hypothalamus, however, showed significant hypothermic action.
4. Injection of chlorpromazine into anterior hytophalamus and preoptic area brought mild h} pothermie action.
In view of these drastic responses of chiorpromizine upon body temperature regulation, it is felt that chlorpromazine acts on many different portions of the brain for hypothermic action.
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